Evidence mapPaperPMID 41386270Full record

ArticleThe Lancet. Public health2026

Temporal trends in associations between social drivers and life-years lost in newly diagnosed atrial fibrillation in Denmark, 2000-22: a nationwide cohort study.

Nicklas Vinter, Søren Paaske Johnsen, Gregory Y H Lip, Ludovic Trinquart, Lars Frost, Emelia J Benjamin

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Article in The Lancet. Public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Nicklas VinterDanish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Cardiology, Regional Hospital Central Jutland, Viborg, Denmark. Electronic address: nicvin@rm.dk.
Søren Paaske JohnsenDanish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Gregory Y H LipDanish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK; Department of Cardiology, Lipidology and Internal Medicine with Intensive Coronary Care Unit, Medical University of Bialystok, Bialystok, Poland.
Ludovic TrinquartDanish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Lars FrostDanish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Cardiology, Regional Hospital Central Jutland, Viborg, Denmark.
Emelia J BenjaminDanish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine and Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Boston University BIRCWHK12AR085635 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Emelia J. Benjamin, JOYCE Y WONG · 2025 to 2026
$2.2M
NHLBI NIH HHS R01 HL092577NIAMS NIH HHS K12 AR085635
6 · The paper itself

Abstract

backgroundIndividuals with atrial fibrillation who are systemically disadvantaged often receive lower quality of care and face higher complications and mortality rates. However, data on survival inequity trends are sparse. We examined temporal trends in associations between social drivers and life expectancy loss among individuals with newly diagnosed atrial fibrillation in Denmark.

methodsIn this nationwide, registry-based, cohort study, we assessed mortality in individuals with newly diagnosed atrial fibrillation. Social drivers at diagnosis included family income (lower, medium, higher), educational attainment (lower, medium, higher), and living alone. For each social driver, we compared age-adjusted and sex-adjusted 10-year restricted mean time lost across subgroups as an absolute measure of inequity in expected survival time. Trends were compared between the periods of 2000-10 and 2011-22.

findingsAmong 383 566 individuals with newly diagnosed atrial fibrillation, restricted mean time lost improved across all levels of social drivers over time. Life-years lost associated with income changed modestly between periods, with a slight reduction in inequity for people with medium versus higher income (-1·65 years [95% CI -1·70 to -1·60] to -1·55 years [-1·59 to -1·50]), but a slight increase for people with lower versus higher income (-2·46 years [-2·55 to -2·37] to -2·51 years [-2·57 to -2·45]; P

interpretationDespite small improvements for income and education, substantial socioeconomic inequities in long-term survival after atrial fibrillation diagnosis persisted over two decades. The findings highlight the urgent need to address the underlying barriers driving the inequities.

fundingDanish Cardiovascular Academy.

Indexed as

Atrial FibrillationHealth Status DisparitiesLife ExpectancySocial Determinants of HealthAdultAgedAged, 80 and overCohort StudiesDenmarkEducational StatusFemaleFollow-Up StudiesHumansIncomeMaleMiddle Aged

Identifiers

PMID41386270
PMCPMC12911257

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.