Evidence map›Paper›PMID 41387112›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia-Reperfusion Injury.

Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xueying ChengDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Shuangyu LiuSchool of Biological Sciences and Medical Engineering, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 201196, China.
Yu ZhangDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Kang PengDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Muge QileDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Chao WuDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Mengyun DouDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Liu LiuDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Na YangDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Rui LiuSchool of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.
Guiyang ZhangSchool of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.
Liangping NiDepartment of Radiology, The Second Affiliated Hospital of Anhui Medical University, Medical Imaging Research Center, Anhui Medical University, Hefei, 230601, China.
Gaolin LiangState Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, 210096, China.
Fang YangSchool of Biological Sciences and Medical Engineering, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 201196, China.
Ye ZhangDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.
Shufang HeDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230601, China.ORCID https://orcid.org/0000-0001-9896-5705

Funding

Anhui Provincial Natural Science Foundation 2208085MH218National Natural Science Foundation of China 32271194National Natural Science Foundation of China 32471195Open Research Fund of State Key Laboratory of Bioelectronics of Southeast University Sklb2021p09Program for Excellent Research and Innovation Team of Higher Education Institutions of Anhui Province 2023AH010081Program for Excellent Research and Innovation Team of Higher Education Institutions of Anhui Province 2024AH010013Research Fund of Anhui Institute of Translational Medicine 2021zhyx-C42Second Affiliated Hospital of Anhui Medical University Seed 2020GQFY06
6 · The paper itself

Abstract

The heat-sensitive transient receptor potential vanilloid 1 (TRPV1), which is highly expressed on cardiac sensory neurons, reportedly plays a crucial role in transmitting nociceptive signals from the heart to the spinal cord during myocardial ischemia and reperfusion. Here, iron oxide nanocubes (FeNCs) are developed that are conjugated with an antibody against the extracellular portion of TRPV1, and they are named FeNCs-TRPV1. In F11 cell line and primary dorsal root ganglion neurons, FeNCs-TRPV1 specifically activate TRPV1 channels and trigger Ca

Indexed as

Myocardial Reperfusion InjuryTRPV Cation ChannelsAnimalsGanglia, SpinalMaleRatsRats, Sprague-DawleySpinal CordTrpv1 protein, ratTRPV Cation Channelsiron oxide nanocubesmagnetothermal effectmyocardial ischemia‐reperfusion injuryspinal cordtransient receptor potential vanilloid 1

Identifiers

PMID41387112
PMCPMC12931263

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.