Evidence map›Paper›PMID 41387476›Full record

ArticleScientific reports2025

Network pharmacology and molecular docking reveal antiviral mechanisms of silver nanoparticles synthesized by Oscillatoria sp. against HCV pathogenesis.

Lamya Azmy, Ebtesam Al-Olayan, Mohamed A A Abdelhamid, Ibraheem B M Ibraheem, Ahmed Zayed, Saly F Gheda, Khayrya A Youssif, Hesham A Abou-Zied, Usama R Abdelmohsen, Seung Pil Pack and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lamya AzmyBotany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt.
Ebtesam Al-OlayanInfectious Disease Vaccines Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Mohamed A A AbdelhamidBiology Department, Faculty of Education and Arts, Sohar University, 311, Sohar, Oman.
Ibraheem B M IbraheemBotany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt.
Ahmed ZayedDepartment of Pharmacognosy, College of Pharmacy, Tanta University, Elguish Street (Medical Campus), Tanta, 31527, Egypt.
Saly F GhedaDepartment of Botany, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Khayrya A YoussifDepartment of Pharmacognosy, Faculty of Pharmacy, El Saleheya El Gadida University, El Sharquia, Egypt.
Hesham A Abou-ZiedDepartment of Medicinal Chemistry, Faculty of Pharmacy, Deraya University, New Minia, 61111, Egypt.
Usama R AbdelmohsenDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia, 61111, Egypt.
Seung Pil PackDepartment of Biotechnology and Bioinformatics, Korea University, Sejong-Ro 2511, Sejong, 30019, Republic of Korea.
Hazim O KhalifaDepartment of Veterinary Medicine, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, United Arab Emirates. hazimkhalifa@uaeu.ac.ae.
Khaled N M ElsayedBotany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt. kelsayed@su.edu.om.

Funding

This work was supported by Ongoing Research Funding Program-Research chairs, (ORF-RC-2025-4500), King Saud University, Riyadh, Saudi Arabia, ORF-RC-2025-4500This work was supported by the United Arab Emirates University (UAEU) Strategic Research Program 2024 grant Proposal number 3702; fund code 12R310) for H.O.K.
6 · The paper itself

Abstract

This study explored the green synthesis of silver nanoparticles (AgNPs) using eco-friendly aqueous and methanolic extracts from Oscillatoria sp. algae. Characterization techniques (Fourier transform infrared spectroscopy, Transmission electron microscopy, Dynamic light scattering technique, and Zeta potential) confirmed the successful synthesis and stability of the AgNPs. Untargeted metabolic profiling via LC-MS tentatively identified 22 potential metabolites (1-22) in the extracts, primarily glycolipids, macrolides, fatty acids, and cyclic polyketides. Notably, the methanolic extract and its derived AgNPs exhibited potent antiviral activity against the Hepatitis C Virus (HCV) in HuH7.5 cells. The AgNPs displayed a significantly lower IC

Indexed as

Antiviral AgentsHepacivirusHepatitis CMetal NanoparticlesSilverHumansMolecular Docking SimulationNetwork PharmacologyAntiviral AgentsSilverAntiviral HCVCyanobacteriaGreen biosynthesisNanotechnologyOscillatoria spSilver nanoparticles

Identifiers

PMID41387476
PMCPMC12708671

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.