ArticleScientific reports2025
Novel zoonotic cases of Plasmodium simium from São Paulo with a reference genome of the Brazilian strain.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Malaria-GENOMAP: a web-based tool for exploring genomic variation of malaria parasites.Bioinformatics (Oxford, England) · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Zoonotic malaria, caused by parasites like Plasmodium simium, poses challenges to control and elimination efforts due to undetected reservoirs and altered transmission dynamics. Recent outbreaks in Brazil underscore the importance of P. simium spillovers from non-human primates. Genomic studies are crucial for identifying molecular markers of host adaptation and improving diagnostic tools; however, a high-quality reference genome is needed. To address this, we used Oxford Nanopore and Illumina sequencing platforms to generate a high-quality P. simium reference (Ps_SãoPaulo, 21.8 Mb). Comparative genomic analyses confirmed known differences with P. vivax, including mitochondrial mutations, deletions in reticulocyte-invasion genes (RBP2a, DBP), and variants in blood-stage antigen genes (msp3.1, msp3.2). Genome-wide analyses of 38 P. simium samples from Brazil revealed expected divergence from P. vivax and potential unique signatures of selection and host adaptation. This study provides the most comprehensive P. simium reference genome, advancing our understanding of its genomic diversity, with insights for malaria control in Brazil.
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Registered trials
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