ArticleNature communications2025
Mediators of the association between psychological distress and mortality in people diagnosed with cancer.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer.Psycho-oncology · 2026Article
- Health-Related Quality of Life in Lung Cancer Survivors: Sociodemographic, Clinical, and Psychosocial Modulators.Current oncology (Toronto, Ont.) · 2026Article
- Metabolic Crosstalk Between Host and Tumor as a Circuit of Resilience in Cancer Therapy.Cells · 2026Review
- Factors associated with serious psychological distress among US adult cancer survivors: a cross-sectional observational analysis of the 2024 National Health Interview Survey.Journal of cancer survivorship : research and practice · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The biological and behavioural mechanisms linking psychological distress to excess mortality in people living with and beyond cancer (LWBC) remain poorly understood. In this multi-cohort study, we examine the associations between psychological distress and both cancer-specific and all-cause mortality in individuals living with and beyond cancer (LWBC), and assess the potential mediating roles of inflammation and health behaviours. The primary analysis includes 13,349 adults from the UK Biobank (2006-2021), with replication in 5739 participants from the Finnish Public Sector study (2000-2018). Psychological distress is associated with an increased risk of all-cause mortality (pooled adjusted risk ratio (RR), 1.54; 95% confidence interval (CI), 1.37-1.74) and cancer mortality (pooled RR, 1.57; 95% CI, 1.37-1.79). Systemic inflammation explains up to 18.6% of these associations, whereas diet, alcohol consumption, and body mass index do not mediate these relationships. Evidence for mediation by other health behaviours is inconsistent. While adjustment for cancer stage attenuates the distress-mortality link by up to 25%, psychological distress remains a robust predictor of both all-cause and cancer mortality. These findings suggest that psychological distress is an independent predictor of mortality risk in people with LWBC, partially attributable to elevated levels of systemic inflammation.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.