SynthesisBMC musculoskeletal disorders2025
Optimal resistance training strategies for knee osteoarthritis symptom relief: a systematic review and network meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- From paradox to population impact: Rethinking strengthening in knee osteoarthritis - A state-of-the-art review.Osteoarthritis and cartilage open · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the most effective resistance training (RT) type and the optimal intensity, duration, and number of repetitions for patients with knee osteoarthritis (KOA).
methodsPubMed, MEDLINE, Embase, CENTRAL, and Web of Science were searched from inception to April 2025 for randomized controlled trials (RCTs) of exercise for KOA. Bayesian network meta-analyses were conducted. The outcomes of pain, stiffness, and function were expressed as standardized mean differences (SMDs) with 95% credible intervals (CrI).
resultsThe analysis included 46 RCTs with 3463 participants. High-speed RT was identified as the most effective type, significantly improving pain (SMD: -1.35, 95% CrI: -1.89 to -0.81), stiffness (SMD: -1.26, 95% CrI: -1.81 to -0.70), and function (SMD: 1.70, 95% CrI: 0.96 to 2.45). Dose-response analysis indicated that moderate-intensity RT (43-47% 1RM) for 35-37 weeks with 610-640 weekly repetitions was optimal for reducing pain (SMD: -0.76, 95% CrI: -1.03 to -0.44) and improving function (SMD: 1.29, 95% CrI: 0.92 to 1.68). For stiffness, a higher number of repetitions and shorter duration (12 weeks, 1200 weekly repetitions) were more effective (SMD: -1.11, 95% CrI: -1.58 to -0.64).
conclusionsThis study identifies high-speed RT as the most effective type for managing KOA and provides optimal RT dosages for different symptoms. These findings emphasize the need for tailored RT programs and provide crucial insights for clinical guidelines and individualized patient care. PROSPERO NUMBER: CRD42024535806.
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