ArticleScientific reports2025
Correlation between spectroscopic and stoichiometric protein to lipid ratios in erythrocyte-derived extracellular vesicles and nanoerythrosomes.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The erythrocyte-derived extracellular vesicles and nanoerythrosomes show high similarities due to their same origins supporting their prosperous applicability for new generations of nanocarrier systems. By the addition of a representant erythrocyte-membrane lipid which is the saturated dipalmitoyl-phosphocholine (DPPC), different morphological and structural changes occurred in function of the increasing DPPC ratio. The integration of guest DPPC molecules, expressed in weight ratio extending to an order of magnitude, yields the formation of standalone nanoerythrosomes (NERYs), while the integration of DPPC molecules is significantly reduced into red blood cell derived extracellular vesicles (RBCEVs) causing aggregations of these EVs. Despite the induced severe and different changes in morphological and structural characteristics, both systems show systematic changes in spectroscopical signals displaying quasi proportional alterations in their spectroscopical protein to lipid ratios. Sample series with controlled different amount of added lipid (DPPC) provide the observance of the correlation between spectroscopic and stoichiometric protein to lipid ratios. Independently from the selected spectroscopic lipid-determination (regarding to carbon-hydrogen and carbonyl vibrations), a linear relationship was observed between the spectroscopic and stoichiometric ratios in both erythrocyte systems (NERYs, RBCEVs) and the determination of an approximative lipid concentration comes to be possible without any lipid analytic.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.