ArticleMammalian genome : official journal of the International Mammalian Genome Society2025
ZDHHC5 and ZDHHC14 promote depression via the mediation of double-negative T cells.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
This study aims to identify palmitoylation modification-related genes involved in depression and to explore the mechanism of gene action through the mediation of immune cells. We analyzed the latest reviews on palmitoylation, integrated palmitoylation-related gene loci, and extracted expression quantitative trait locus (eQTL) data for palmitoylation genes associated with depression. Through batch analysis, we initially identified positive genes and validated them using Mendelian randomization based on summary data (SMR) to pinpoint the target genes. Subsequently, we further conducted mediation analysis to explore the downstream mechanism of action of the target gene. In the results, Thirty-one palmitoylated genes were screened from the literature. After extracting eQTL data to obtain 22 co-located loci, batch analysis with depression yielded seven positive genes. Validation using SMR analysis identified ZDHHC5 (OR = 1.136755, P = 1.14 × 10⁻⁹, P
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