ReviewJournal of molecular medicine (Berlin, Germany)2025
The multifaceted roles of MCAM in development, homeostasis, pathological conditions, and cancer.
Review in Journal of molecular medicine (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Construction of a prediction model for retinopathy of prematurity based on placenta-derived genes and clinical variables.Translational pediatrics · 2026Article
- Article
- Biological properties of soluble CD146 and its role and mechanisms in disease progression.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
MCAM (melanoma cell adhesion molecule), identified in human melanoma in 1987, has garnered attention due to its diverse roles in development, homeostasis, and various diseases, including cancer. Initially recognized for its differential expression in tumors, MCAM plays a crucial role in cell adhesion, migration, and signaling. It acts as a receptor for multiple ligands, impacting angiogenesis, inflammation, and immune responses. MCAM is expressed in developing embryos and is implicated in trophoblast invasion during implantation, serving as a marker for placental health. In adults, MCAM is predominantly found in the vascular system and modulates endothelium homeostasis and inflammatory processes. Moreover, its involvement in cancer is marked by associations with tumor progression, particularly through epithelial-mesenchymal transition (EMT) pathways, highlighting its potential as a prognostic biomarker. Elevated levels of soluble MCAM have been linked to poor outcomes in various malignancies and can influence tumor microenvironments. This review synthesizes current understanding of MCAM's multifunctional roles, its bidirectional influence in health and disease, and its potential as a therapeutic target in cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.