Evidence map›Paper›PMID 41388323›Full record

ArticleBMC psychology2025

Effects of occupational stress on the distribution of circulating T lymphocyte subsets and psychological health of young anaesthesiologists.

Rui Xu, Wenyi Chen, Jianshe Wang, Xiahao Ding, Shouqiang Zhu, Xue Han, Yiming Zhou, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. PreoperativeFrontiers in bioinformatics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rui Xu *Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China.
Wenyi Chen *Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China.
Jianshe Wang *Department of Anesthesiology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Xiahao DingDepartment of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China.
Shouqiang ZhuDepartment of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China.
Xue HanDepartment of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China.
Yiming ZhouDepartment of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China.
Zhengliang MaDepartment of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China. mazhengliang1964@nju.edu.cn.
Tianjiao XiaMedical School of Nanjing University, No. 163 Xianlin Avenue, Nanjing, 210023, China. tjxia@nju.edu.cn.
Xiaoping GuDepartment of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China. xiaopinggu@nju.edu.cn.

Funding

Jiangsu Provincial Medical Key Discipline ZDXK202232National Natural Science Foundation of China 82171193
6 · The paper itself

Abstract

backgroundHigh-intensity work environments and high psychological stress place anaesthesiologists in a state of chronic stress. T lymphocyte subsets are an essential component of the peripheral immune cells and are important in the pathophysiology of chronic stress. The aim of this study was to investigate the levels of psychological stress, the expression levels of circulating T lymphocyte subsets, and the correlation between them.

methodsThis study included 61 participants from two tertiary hospitals in Nanjing, China. The Chinese Perceived Stress Scale (CPSS), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) scales were used to assess psychological stress levels. The percentage of circulating T lymphocyte subsets was determined using flow cytometry.

resultsThe proportion of anaesthesiologists with high stress levels was 45.90%. The numbers of γδT cells, T helper 1 (Th1) cells, T helper 17 (Th17) cells, and the ratio of Th17/regulatory T (Treg) cells exhibit significant differences in T lymphocyte subsets across different psychological stress levels. γδT, Th1, and Th17 cell counts were higher in high-stress participants with anxiety and depression than in others.

conclusionsHigh occupational stress is associated with negative emotions and may also affect some subsets of circulating T lymphocytes in young anaesthesiologists.

trial registrationChinese Clinical Trial Registry, ChiCTR1900021637. Registered on 2 March 2019, https://www.chictr.org.cn/showproj.html?proj=29630 .

Indexed as

AnesthesiologistsMental HealthOccupational StressStress, PsychologicalT-Lymphocyte SubsetsAdultAnxietyChinaDepressionFemaleHumansMaleYoung AdultAnaesthesiologistsStressTh cellT lymphocytesTreg cellΓδT cell

Identifiers

PMID41388323
PMCPMC12699846

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.