Evidence map›Paper›PMID 41388327›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2026

Age- and Sex-Adjusted Body Mass Index Increases in Childhood Acute Lymphoblastic Leukaemia Patients From Diagnosis to Five-Year Follow-Up.

Aino Kytömäki, Anu Huurre, Päivi M Lähteenmäki, Tero Vahlberg, Liisa S Järvelä

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Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

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5 authors.

Aino KytömäkiDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Anu HuurreDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Päivi M LähteenmäkiDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Tero VahlbergDepartment of Biostatistics, University of Turku, Turku, Finland.
Liisa S JärveläDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.ORCID 0000-0002-2168-3635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimChildren with acute lymphoblastic leukaemia (ALL) are at risk of metabolic and cardiovascular complications. We evaluated the development of overweight and obesity for 5 years after diagnosis in children and adolescents treated for ALL.

methodsThe medical records of children diagnosed with ALL at one centre during 2000-2018 were assessed. Weight and height measurements were retrieved from medical records and were used to calculate age- and sex-adjusted International Obesity Task Force-Body Mass Index (ISO-BMI). ISO-BMI was determined at selected time points during treatment and up to 5 years after diagnosis, and the change in mean ISO-BMI was assessed.

resultsWe studied 115 patients diagnosed with ALL, 54 (47%) of whom were male. Mean age at diagnosis was 6.6 ± 4.6 (range 0-17.99) years. ISO-BMI increased significantly during treatment (p < 0.0001) and remained elevated at 5 years after diagnosis (p < 0.0001). The number of overweight and obese patients increased from 17% and 4% at diagnosis to 26% and 16% at the five-year follow-up.

conclusionsPatients treated for ALL are at significant risk of weight gain and obesity, with the prevalence of overweight and obesity doubling from diagnosis to 5 years post-treatment. ISO-BMI remained persistently elevated across all treatment risk groups.

Indexed as

Body Mass IndexPediatric ObesityPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentAge FactorsChildChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleOverweightRetrospective StudiesSex Factorsacute lymphoblastic leukaemiachildhood cancer survivorlate effect of childhood canceroverweightweight gain

Identifiers

PMID41388327
PMCPMC12975688

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