ArticleBiology of sex differences2025
Sexual dimorphism of the ventral premammillary nucleus of the rat: stereological evaluation.
Article in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Whole-Brain Connectome Identifies PMvCells · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ventral premammillary nucleus (PMv), situated within the ventrobasal hypothalamus, is sensitive to steroid hormones and is involved in pheromone-responsive circuits. It maintains robust connections with sexually dimorphic nuclei both within and beyond the hypothalamus. Investigations over the past 15 years have suggested the role of the PMv in integrating environmental cues from conspecifics with internal states, thereby facilitating appropriate physiological and behavioral responses during reproductive and agonistic interactions. Neurochemical evidence indicates sexual dimorphism in the PMv of rats; however, comprehensive structural analyses are lacking.
methodsAfter perfusing and processing the brains of male and female rats during the estrus and diestrus phases, we applied stereological methodology in the PMv.
resultsMales presented significantly greater neuronal volume and quantity than females did across both cycling phases. Neuronal volume in females was notably greater during estrus than during diestrus. However, no dimorphism was detected in overall volume, neuronal density, volume occupied by neurons, or neuropils.
conclusionsGiven its role as a nexus between nutritional status and reproductive physiology, as well as its involvement in modulating agonistic behavior, including maternal aggression, structural disparities in the PMv between males and females may reflect divergent functional roles, contributing to sex-specific strategies in reproduction and aggression.
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