ArticleBMC psychiatry2025
Inflammatory indices are associated with non-suicidal self-injury in adolescents with major depressive disorder.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Competing-Risk Nomogram for in-Hospital Non-Suicidal Self-Injury Recurrence Using Inflammatory and Clinical Predictors.Risk management and healthcare policy · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP)-albumin ratio (CAR) constitute peripheral inflammatory indices. This study aimed to evaluate the correlation between these inflammatory indices and non-suicidal self-injury (NSSI) behavior in adolescents with major depressive disorder (MDD).
methodsAdolescents diagnosed with MDD were enrolled in this study. All participants underwent psychological and biochemical assessments and were classified into two groups based on the presence or absence of NSSI. NLR, MLR, PLR, and CAR were calculated from complete blood counts.
resultsA total of 101 adolescents with MDD were included. No significant differences were observed in the demographic data between the groups. The NSSI group had significantly higher levels of white blood cells, neutrophils, NLR, MLR, and CAR, and lower albumin levels than the non-NSSI group. Multivariate regression analysis revealed that NLR and MLR were independently associated with NSSI. The proposed cut-off values were NLR = 1.23 (sensitivity = 70.2% and specificity = 59.1%) and MLR = 0.14 (sensitivity = 77.2% and specificity = 43.2%).
conclusionsSystemic inflammation may play a role in NSSI among adolescents with MDD. NLR and MLR, as cost-effective and easily accessible indices, are associated with NSSI, but further longitudinal studies are required to determine their predictive value. CLINICAL TRIAL NUMBER: Not applicable.
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