ArticleTrials2025
Comparison of morning vs evening exercise on weight loss and related health behaviors in individuals with overweight or obesity: study protocol for a 56-week randomized controlled trial (TIMEX).
Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02153252, which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundAerobic exercise is recommended for weight management. Recent evidence suggests that there may be time-dependent differences in how exercise affects body weight and energy balance regulation. The primary purpose of this study is to determine the effect of morning versus evening aerobic exercise on changes in body composition and components of energy balance in adults with overweight and obesity.
methodsThe Timing Intervention of Morning versus Evening EXercise (TIMEX) study is a two-arm, 56-week, block randomized (1:1) aerobic exercise intervention. One hundred twenty-eight adults with overweight and obesity will be randomized to engage in morning (AM-Ex, 06:00-10:00) or evening (PM-Ex, 15:00-19:00) moderate- to-vigorous intensity aerobic exercise progressing to 2000 kcal/week of energy expenditure. The primary outcome is change in body weight at 7 months. Secondary outcomes include changes in body composition, energy intake, hunger and eating behaviors, energy expenditure, and physical activity behaviors at 7 and 13 months. DISCUSSION: Aerobic exercise elicits modest weight loss; however, there is substantial inter-individual variability in the weight loss response with some individuals losing significant amounts of weight and others gaining weight. The time of day exercise is performed may contribute to this weight loss variability. Understanding how the time of day of exercise affects weight loss and components of energy balance may lead to tailored exercise interventions that enhance weight loss. The TIMEX study will determine the effect of a guidelines-based dose of aerobic exercise completed in the morning versus the evening on weight loss, energy intake, and energy expenditure.
trial registrationClinicalTrials.gov NCT02153252. Registered on 12/10/2021.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.