Observational studyAIDS research and therapy2025
Kidney dysfunction in adults living with HIV and HBV: a 10-year retrospective cohort study across seven Asia-Pacific countries.
Observational study in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated kidney dysfunction among people with HIV (PWH), comparing those with and without hepatitis B virus (HBV) co-infection. We further identified predictors of kidney dysfunction in PWH with HBV.
methodsAdult PWH in the TREAT Asia Observational Database-Low Intensity TransfEr cohort, who were on antiretroviral therapy, with follow-up after 2010 were included. HBV co-infection was defined by positive hepatitis B surface antigen. Kidney dysfunction was determined as a single estimated glomerular filtration rate < 60mL/min/1.73m
resultsAmong 23,415 participants (median age = 37 years; interquartile range [IQR]: 31-43), most were male (62.2%), from lower-middle income countries (67.1%), and reported heterosexual HIV transmission (79.3%). The median follow-up time was 5.41 years (IQR: 2.05-8.67). The majority were prescribed NRTI + NNRTI (83.6%), and 4.9% had HBV co-infection. Overall, 8.0% had kidney dysfunction, with a higher proportion among PWH with HBV than those without HBV (14.8% vs. 7.6%, p < 0.001). Most cases of kidney dysfunction were stage III (84.2%). Factors associated with kidney dysfunction in PWH with HBV included older age (≥ 50 years: Hazard ratio [HR] = 6.45, 95%CI: 2.31, 18.04) compared to 18-29 years, higher income country (upper-middle income: HR = 1.78, 95%CI: 1.16, 2.74) compared to lower-middle income, low platelet counts (< 150 × 10
conclusionsA high prevalence of kidney dysfunction was observed among PWH with HBV co-infection in the Asia-Pacific. Renal screening and monitoring should prioritize PWH with HBV with older age, low platelets and CD4 counts in low-resource settings.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.