ReviewAnnals of medicine2025
Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective.
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Effect of Umbilical Cord-Derived Mesenchymal Stem Cells and Secretome on Metabolomic Profiles (C-Peptide, Adiponectin, Fasting Insulin, and Fasting Glucose): A Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- The Impact of Oxidative Stress Imbalance on Ovarian Function and Its Mechanisms.International journal of general medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCellular senescence is often linked to diseases or states of dysfunction, including reproductive disorders caused by ovarian dysfunction. It plays a significant role in conditions like polycystic ovary syndrome (PCOS). However, the specific effects and potential mechanisms of cellular senescence in PCOS need to be elucidated.
methodsThis review comprehensively consolidates evidence from original research articles and systematic reviews to explore the association between PCOS and cellular senescence, particularly emphasizing cell senescence markers and mechanisms linked to various PCOS phenotypes. In addition, it also covers potential mechanisms and advances in cellular senescence-related treatment methods in PCOS.
resultsCurrent evidence suggests that cellular senescence might contribute to PCOS through mechanisms such as replicative senescence, stress-induced premature senescence, and immunoinflammatory responses mediated by senescent cells. Key features of senescence, including cell cycle arrest, the senescence-associated secretory phenotype (SASP), epigenetic changes, abnormal cell morphology, oxidative stress, DNA damage from telomere shortening and telomerase inhibition, and overactivation of anti-apoptotic pathways, are all related to PCOS. These mechanisms might especially impair follicular development in obese, hyperandrogenic, or insulin-resistant patients with PCOS, leading to endometrial hyporeceptivity and increased pregnancy complications. Senolytic and senomorphic drugs are valuable clinical treatments for PCOS respectively targeted to immune surveillance mechanisms of senescent cells or mitigated the harmful effects of senescent cells on intercellular communication.
conclusionsThere is a complex correlation mechanism between cellular senescence and PCOS. Studying these cellular senescence markers and mechanisms in PCOS could provide new insights into the pathogenesis, and lay the groundwork for in-depth study and potential application of anti-senescence therapies in treating PCOS.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.