Evidence map›Paper›PMID 41388800›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease.

Saira S Mirza, Sarah Duff-Canning, Mark Mapstone, Susan Fox, Sandra E Black, Malcolm A Binns, David P Breen, Keera N Fishman, David A Grimes, Anthony E Lang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Saira S MirzaThe Sandra Black Centre for Brain Resilience and Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0973-2246
Sarah Duff-CanningThe Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Mark MapstoneDepartment of Neurology, The University of California, Irvine, California, USA.
Susan FoxThe Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Sandra E BlackThe Sandra Black Centre for Brain Resilience and Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
Malcolm A BinnsRotman Research Institute, Baycrest Health Sciences, North York, Ontario, Canada.
David P BreenCentre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.
Keera N FishmanNeuropsychology and Cognitive Health Program, Baycrest Hospital, North York, Ontario, Canada.
David A GrimesDivision of Neurology/Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Anthony E LangThe Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Brian LevineRotman Research Institute, Baycrest Health Sciences, North York, Ontario, Canada.
Paula M McLaughlinDepartment of Medicine, Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Angela K TroyerNeuropsychology and Cognitive Health Program, Baycrest Hospital, North York, Ontario, Canada.
Mario MasellisThe Sandra Black Centre for Brain Resilience and Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
Connie MarrasThe Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

Funding

Brain CanadaCanadian Institutes of Health Research (CIHR) 126052EU Joint Programme - Neurodegenerative Disease ResearchOntario Brain Institute 126052Women's Brain Health Initiative
6 · The paper itself

Abstract

introductionCurrently, our ability to predict cognitive decline in Parkinson's disease is limited.

methodsIn 234 dementia-free PD patients, cognitive profiles at baseline were determined using cluster analysis and longitudinal associations with global cognitive z-score, health-related quality of life (HR-QoL), caregiver burden, and risk of reliable cognitive change (RCC) were tested.

resultsParticipants fell into four cognitive profiles at baseline: normal cognition (n = 108), memory impairment (n = 47), memory and executive function impairment (n = 59), and global cognitive impairment (n = 20). After adjusting for the severity of cognitive impairment, only the memory impairment cluster showed a higher risk of RCC. Baseline cognitive profiles did not predict different rates of cognitive decline, change in HR-QoL, or caregiver burden. DISCUSSION: The memory impairment cluster showed a higher risk of developing a reliable cognitive change; however, baseline cognitive profiles did not consistently predict different rates of cognitive decline, HR-QoL, or caregiver burden. HIGHLIGHTS: Data-driven approach to identify cognitive profiles. Cognitive decline across domains assessed by risk of reliable cognitive change. Cognitive profiles did not predict rate of cognitive decline. Memory impairment profile had a higher risk of reliable cognitive change.

Indexed as

CognitionCognitive DysfunctionParkinson DiseaseQuality of LifeAgedCaregiversExecutive FunctionFemaleHumansLongitudinal StudiesMaleMemory DisordersMiddle AgedNeuropsychological Testscaregiver burdencognitive profilescognitive subtypingHR‐QoLlongitudinalPDQ‐39reliable cognitive changesurvival analysisZarit burden inventory

Identifiers

PMID41388800
PMCPMC12701370

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.