Evidence map›Paper›PMID 41388939›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Ras Homolog Enriched in Brain Protein Reverses Amyloid Beta-Induced Escape of Inflammatory Cytokine mRNAs From Immunoisolated RNA Processing Bodies of Glioblastoma Cells.

Sritama Ray, Kamalika Mukherjee, Suvendra N Bhattacharyya

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sritama RayCSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India.ORCID https://orcid.org/0009-0008-4701-2144
Kamalika MukherjeeDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0001-6520-4846
Suvendra N BhattacharyyaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0001-9697-3824

Funding

CEFIPRA 6003-JSERB, Department of Science and Technology, Govt. of India High-RiskHigh-RewardGrant(HRR/2016/000093)The Department of Science and Technology, Govt. of India SwarnajayantiFellowship(DST/SJF/LSA-03/2014-15)UNMC|College of Medicine, University of Nebraska Medical Center (COM, UNMC) LiebermanResearchFund2025_MukherjeeUNMC|College of Medicine, University of Nebraska Medical Center (COM, UNMC) StartUpFundBhattacharyya
6 · The paper itself

Abstract

Post-transcriptional regulation by RNA processing bodies, also known as P-bodies (PBs), is vital for mRNA translation, localization, and stability in various animal cells, including neurons and glial cells. PBs enable spatial control of protein synthesis, influencing differentiation and synaptic function. Understanding mRNA storage within PBs is essential for identifying the mechanism controlling post-transcriptional gene expression in brain cells and for understanding its role in neurodegenerative diseases. We developed a detergent-based method to isolate phase-separated P-bodies, free of cytosolic factors and RNAs, enabling us to analyze the mRNA content of PBs under different cellular or experimental conditions. Using neuronal (NGF-differentiated PC12) and glial cell (C6 glioblastoma) models, we studied how Aβ

Indexed as

Amyloid beta-PeptidesCytokinesGlioblastomaPeptide FragmentsRNA, MessengerRNA Processing, Post-TranscriptionalAnimalsCell Line, TumorHumansNeuronsPC12 CellsRatsAmyloid beta-Peptidesamyloid beta-protein (1-42)CytokinesPeptide FragmentsRNA, Messengeramyloid betacytokine expressionmRNAneuroinflammationphase‐separated structuresRNA processing bodies

Identifiers

PMID41388939
PMCPMC12701684

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.