Evidence map›Paper›PMID 41389078›Full record

ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2026

Exercise and Kidney Health: Core Curriculum 2026.

Laura Aponte Becerra, Sherry G Mansour

Abstract readReview
In one paragraph

Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura Aponte BecerraSection of Nephrology, School of Medicine, Yale University, New Haven, Connecticut.
Sherry G MansourSection of Nephrology, School of Medicine, Yale University, New Haven, Connecticut. Electronic address: sherry.mansour@yale.edu.

Funding

Evaluation of Angiopoietins as Prognostic Markers of Kidney Allograft Structure and FunctionK23DK127154 · NIDDK · YALE UNIVERSITY · PI MANSOUR, SHERRY GEORGE · 2021 to 2025
$1.0M
NIDDK NIH HHS K23 DK127154NIDDK NIH HHS L30 DK130080
6 · The paper itself

Abstract

Exercise triggers complex effects on kidney physiology that vary with intensity, duration, and environmental conditions. While moderate physical activity improves cardiovascular and renal outcomes, intense or prolonged exertion, particularly in endurance sports, can lead to acute kidney injury. Adaptations in kidney physiology during exercise include reduced plasma flow, altered glomerular filtration, and hormone-mediated fluid retention. These changes are protective but may become maladaptive with dehydration, heat stress, or excessive fluid intake. High-intensity exercise increases oxidative stress and proteinuria, while ultramarathon participation may cause transient creatinine elevation from muscle breakdown, complicating acute kidney injury diagnosis. Prevention strategies include individualized hydration plans, electrolyte replacement, and avoidance of nonsteroidal anti-inflammatory drugs. In special populations, such as children with chronic kidney disease or patients receiving dialysis, structured exercise enhances quality of life and physical function when implemented safely. Clinicians must balance the benefits of exercise with kidney-related risks, promote safe training practices, and recognize early signs of exertional complications to optimize renal and overall health in physically active individuals. This core curriculum reviews the physiology of exercise on kidney function and provides evidence-based strategies for patient counseling and risk reduction.

Indexed as

Acute Kidney InjuryCurriculumExerciseKidneyHumansRenal Insufficiency, ChronicAcute kidney injurychronic kidney diseasedialysisexerciseheat stresshigh-intensity exercisehydrationhyponatremianutritional supplementationrhabdomyolysis

Identifiers

PMID41389078
PMCPMC12704824

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.