Evidence map›Paper›PMID 41389307›Full record

ReviewCellular and molecular neurobiology2025

Advances in Bionic Therapies for Targeting Neural Circuit Reconstruction and Integration for Spinal Cord Injury.

Tao Li, Zhi-Hong Zhao, Hai-Bin Tang, Zhe Chen, Zi-Wei Lu, Xue-Ling Yang, Li-Li Zhao, Ye Li, Mei-Juan Dang, Zi-Yi Chen and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tao LiDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China.ORCID http://orcid.org/0000-0003-2045-220X
Zhi-Hong ZhaoDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China.ORCID http://orcid.org/0009-0004-2039-3582
Hai-Bin TangDepartment of Laboratory Medicine , Xi'an Central Hospital Xi'an Jiaotong University , Xi'an, 710003, Shaanxi, China.ORCID http://orcid.org/0009-0008-6930-7832
Zhe ChenDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China.ORCID http://orcid.org/0000-0002-7266-0038
Zi-Wei LuDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China.ORCID http://orcid.org/0000-0003-1553-3291
Xue-Ling YangDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China.ORCID http://orcid.org/0009-0008-8537-3215
Li-Li ZhaoDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China.ORCID http://orcid.org/0000-0002-1136-8981
Ye LiDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China.ORCID http://orcid.org/0000-0002-4401-4258
Mei-Juan DangDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China.ORCID http://orcid.org/0000-0002-2230-4908
Zi-Yi ChenLineberger Comprehensive Cancer Center , University of North Carolina at Chapel Hill , Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0003-2933-3274
Gui-Lian ZhangDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China. zhgl_2006@xjtu.edu.cn.ORCID http://orcid.org/0000-0002-9682-093X
Ling LiuMilitary Medical Innovation Center Department of Neurobiology and Institute of Neurosciences , Fourth Military Medical University , 169 Chang Le Xi Road, Xi'an, 710032, Shaanxi, China. liuling@fmmu.edu.cn.ORCID http://orcid.org/0000-0002-5326-5518
Hong FanDepartment of Neurology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, 710004, Shaanxi, China. fanhong@xjtu.edu.cn.ORCID http://orcid.org/0000-0003-4987-2582

Funding

National Natural Science Foundation of China 82101551National Natural Science Foundation of China 82171361National Natural Science Foundation of China 82171471National Natural Science Foundation of China 82471333
6 · The paper itself

Abstract

Spinal cord injury (SCI) is one of the most common critical illnesses, which can cause neurological deficits and disabilities of motor, sensory and autonomic nervous system in mild cases, and lead to paralysis or even death following severe trauma. Although there are currently no effective and satisfactory clinical treatments, the efforts for repair SCI never stop. Besides the traditional strategies such as drugs, surgical interventions and rehabilitative care, the bionic therapies have attracted significant attention due to its considerable promise. The bionic therapies for SCI mainly included engineered biomaterials-based approaches aiming for reconstruction of internal neural circuit and brain machine interfaces (BMI)-based technologies to integrate extrinsic control and intrinsic circuit. This review provides an extensive overview of SCI research and bionic therapies, with focus on reconstruction and integration of neural circuit, which might provide promising insights on clinical treatment.

Indexed as

BionicsNerve NetSpinal Cord InjuriesAnimalsBrain-Computer InterfacesHumansBionic therapiesBrain machine interfacesFunctional replacementNeural circuitsSpinal cord injury

Identifiers

PMID41389307
PMCPMC12804578

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.