ArticleExperimental neurology2026
Cholinergic modulation of hippocampal CA1 pyramidal cell excitability in Arx
Christopher M Johnson, Joseph Dong, Peace Senkungu, Jahnvi Chandar, Natalia Ochoa-Sepulveda, Almedia J Myers, Eric D Marsh
Abstract read
In one paragraphArticle in Experimental neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Christopher M JohnsonDivision of Child Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, USA. Electronic address: johnsonc22@chop.edu.
Joseph DongDivision of Child Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, USA. Electronic address: dongjp@chop.edu.
Peace SenkunguDivision of Child Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, USA. Electronic address: senkungup@chop.edu.
Jahnvi ChandarDivision of Child Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, USA. Electronic address: jahnvichandar@students.aucmed.edu.
Natalia Ochoa-SepulvedaDivision of Child Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, USA.
Almedia J MyersDivision of Child Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, USA. Electronic address: amyers@coriell.org.
Eric D MarshDivision of Child Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, USA; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: marshe@chop.edu.
Funding
The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2MTraining Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9MSeizure generation and network excitability in Arx related Infantile SpasmsR01NS082761 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI MARSH, ERIC D · 2013 to 2017
$1.8MNICHD NIH HHS P50 HD105354NINDS NIH HHS R01 NS082761NINDS NIH HHS T32 NS007413
6 · The paper itselfAbstract
Developmental and Epileptic Encephalopathies (DEE) are rare neurodevelopmental disorders defined by seizures, developmental delays, and abnormal EEG patterns. Infantile Spasms Syndrome (ISS), the most common DEE, was one of the first linked to single-gene variants, including polyalanine expansions in the Aristaless Related Homeobox (ARX) gene. The Arx
Indexed as
CA1 Region, HippocampalHomeodomain ProteinsPyramidal CellsAnimalsCholine O-AcetyltransferaseMaleMiceMice, Inbred C57BLMice, TransgenicCholine O-AcetyltransferaseHomeodomain ProteinsAcetylcholineAristaless related homeoboxDepolarization blockDevelopmental and epileptic encephalopathyHippocampusInfantile spasms syndromeWest syndrome
Identifiers
PMID41390005
PMCPMC13150844
What Socratic holds
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