Evidence map›Paper›PMID 41390334›Full record

ArticleNPJ biofilms and microbiomes2025

Ruminococcus bromii alleviates constipation by pullulanase-driven resistant starch degradation and microbiota modulation.

Rong Li, Qianqian Yang, Junqing He, Min Li, Qiang Ding, Kun Tian, Wei Yang, Guoxing Zhang, Aihua Guo, Man Gu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The Effect ofBiology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rong Li *Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Qianqian Yang *Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Junqing HeKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Min LiKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Qiang DingDepartment of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Kun TianDepartment of Gastroenterology, Pufang Hospital, Chibi, Hubei, China.
Wei YangDepartment of Gastroenterology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Guoxing ZhangDepartment of Gastroenterology, Huangshi Central Hospital, Huangshi, Hubei, China.
Aihua GuoDepartment of Gastroenterology, The First People's Hospital of Xiaogan City, Xiaogan, Hubei, China.
Man GuDivision of geriatric Gastroenterology, The First Afliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Qin YuDepartment of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Haidong JiaShanghai Jahwa United Co., Ltd., Shanghai, China.
Dezheng XuShanghai Jahwa United Co., Ltd., Shanghai, China.
Hongju YangDivision of geriatric Gastroenterology, The First Afliated Hospital of Kunming Medical University, Kunming, Yunnan, China. yanghongju@kmmu.edu.cn.
Huaping XieDepartment of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. hpxie@tjh.tjmu.edu.cn.
Weihua ChenKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. weihuachen@hust.edu.cn.
Zhi LiuKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. zhiliu@hust.edu.cn.

Funding

National Key Research and Development Program of China 2024YFA0918500Project of Yunnan Applied Basic Research Project Kunming Medical University Union Foundation 202201AY070001-042the Famous Medical Specialist of "High-level Talent Training Support Program" in Yunnan Province YNWR-MY-2019-036the Hubei Provincial Natural Science Foundation of China 2024AFB829the Innovative Team of Yunnan Province 202305AS350019Yunnan Expert Workstation 202505AF350080Yunnan Provincial Key Research and Development Plan 202403AC100020
6 · The paper itself

Abstract

Constipation is a prevalent gastrointestinal disorder associated with alterations in the gut microbiota. However, the potential microbial targets and their underlying mechanisms remain to be explored. Our analysis found the genus Ruminococcus was depleted in constipated patients. We then tested four species, R. bromii, R. torques, R. obeum, and R. gnavus, in constipated mice, finding all alleviated symptoms. R. bromii was most effective, with its pullulanase enzyme being key to degrading resistant starch. This degradation boosted short-chain fatty acid production and fostered beneficial bacteria like Akkermansia and Bifidobacterium. A subsequent clinical trial confirmed that the constipation-relieving effect of dietary resistant starch was dependent on the presence and abundance of R. bromii in the gut. This study identifies R. bromii as a key microbial mediator for constipation relief through resistant starch metabolism, positioning it as a promising candidate for targeted probiotic or synbiotic therapies.

Indexed as

ConstipationGastrointestinal MicrobiomeGlycoside HydrolasesRuminococcusStarchAkkermansiaAnimalsBifidobacteriumDisease Models, AnimalFatty Acids, VolatileFecesFemaleHumansMaleMiceProbioticsFatty Acids, VolatileGlycoside HydrolasespullulanaseStarch

Identifiers

PMID41390334
PMCPMC12789625

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.