ArticleDiabetology & metabolic syndrome2025
The relation between tirzepatide and adverse cardiovascular events or renal adverse events: a meta-analysis based on randomized controlled trials.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundThis meta-analysis aimed to evaluate the relation between tirzepatide exposure and the risk of adverse cardiovascular or renal events in participants with type 2 diabetes mellitus (T2DM) or obesity.
methodsA comprehensive search was conducted from inception until 17th September 2025 across PubMed, Web of Science, EMBASE, ScienceDirect, and ClinicalTrials.gov. Randomized controlled trials (RCTs) comparing tirzepatide with a control group (placebo or other active treatments) in participants with T2DM or obesity that reported adverse cardiovascular events (myocardial infarction (MI), coronary artery disease (CAD), heart failure (HF), and stroke) or adverse renal events (urinary tract infections, kidney stones, renal impairment, renal cell carcinoma) were included. Risk ratios (RR) with 95% confidence intervals (CI) were set to evaluate.
resultsA total of 20 RCTs involving 15,905 participants were included. Overall, no significant relation was observed between tirzepatide exposure and adverse cardiovascular events (RR = 0.83, 95%CI: 0.63–1.08, p = 0.16, I²=0%) or adverse renal events (RR = 1.22, 95%CI: 0.78–1.89, p = 0.39, I²=0%) compared with the control group. Subgroup analyses based on indication (T2DM or obesity), subtype of adverse cardiovascular events, subtype of adverse renal events, dose of tirzepatide, and type of comparator showed no significant differences between the tirzepatide and control groups.
conclusionIn participants with T2DM or obesity, no significant difference between exposure group and control group was observed in our findings. However, longer-term safety, especially in high-risk groups, cannot be ascertained due to heterogeneous outcome definitions and short follow-up durations.
trial registrationThe study was registered with PROSPERO and the ID number is CRD420251054743.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.