Evidence map›Paper›PMID 41390607›Full record

ArticleBMC pediatrics2025

Atopic diseases in pediatric population: prematurity and small for gestational age.

Yi-Yu Su, Chi-Jen Chen, Mei-Huei Chen, Ching-Chun Lin, Chin-Kan Chan, Wu-Shiun Hsieh, Hsi Chang, Chung-Ming Chen, Hsiu-Chen Lin, Pau-Chung Chen

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Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yi-Yu SuInstitute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Room 733, 17 Xu-Zhou Road, Taipei, 10055, Taiwan.
Chi-Jen ChenInstitute of Epidemiology and Preventive Medicine, National Taiwan University College of Public Health, Taipei, Taiwan.
Mei-Huei ChenInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Ching-Chun LinInstitute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Room 733, 17 Xu-Zhou Road, Taipei, 10055, Taiwan.
Chin-Kan ChanDepartment of Pediatrics, Taoyuan General Hospital, Taoyuan, Taiwan.
Wu-Shiun HsiehDepartment of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
Hsi ChangDepartment of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan.
Chung-Ming ChenDepartment of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan.
Hsiu-Chen LinDepartment of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Pau-Chung ChenInstitute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Room 733, 17 Xu-Zhou Road, Taipei, 10055, Taiwan. pchen@ntu.edu.tw.

Funding

National Health Research Institutes NHRI-EM-113-GP-03, NHRI-EM-114-GP-03Taipei Medical University Hospital 110TMUH-NE-07Tao Yuan General Hospital, Ministry of Health and Welfare PTHN113012
6 · The paper itself

Abstract

backgroundAtopic diseases, including asthma, atopic dermatitis (AD), allergic rhinitis (AR), and food allergy, are significant chronic conditions in the pediatric population. Prematurity and small-for-gestational-age (SGA) status are critical factors influencing long-term health outcomes. This study investigated the associations between prematurity, SGA, and the development of atopic diseases in children using a nationwide longitudinal cohort.

methodsWe analyzed data from Taiwan's National Health Insurance Research Database (NHIRD), which includes nearly all residents. The cohort comprised infants born between January 1, 2004, and December 31, 2019, excluding those with early death and multiple births. Premature or SGA infants were designated as study cases, while term, appropriate-for-gestational-age (AGA) infants served as controls. Kaplan-Meier analysis estimated cumulative incidence, and log-rank tests compared disease risk across groups. Cox proportional hazards models, adjusted for demographics, pregnancy-related factors, socioeconomic status, and urbanization, were used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs).

resultsA total of 1,758,460 infants (914,713 males; 843,747 females) were included. Prematurity was associated with increased risks of AR (HR, 1.03) and asthma (HR, 1.19 in males; HR, 1.17 in females) but a lower risk of AD (HR, 0.94 in males; HR, 0.95 in females) in the AGA group. SGA was not associated with atopic diseases in term infants.

conclusionPrematurity was linked to higher risks of asthma and AR and a lower risk of AD, while SGA status showed no association with atopic diseases in term infants. Further studies are needed to clarify underlying mechanisms and assess causality.

Indexed as

Dermatitis, AtopicInfant, PrematureInfant, Small for Gestational AgeAsthmaChildChild, PreschoolDatabases, FactualFemaleHumansIncidenceInfantInfant, NewbornLongitudinal StudiesMaleProportional Hazards ModelsRhinitis, AllergicAllergic rhinitisAsthmaAtopic dermatitisPrematuritySmall for gestational age

Identifiers

PMID41390607
PMCPMC12821825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.