ArticleBMC nephrology2025
Blood pressure response index and acute kidney injury progression in heart failure patients: a retrospective cohort study from MIMIC-IV.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn heart failure (HF), acute kidney injury (AKI) is an independent risk factor of mortality, and severer stage of AKI is associated with poorer prognosis. Blood pressure response index (BPRI) reflects the cardiovascular response to vasoactive drugs which are commonly used to increase perfusion to the vital organs. We sought to investigate the association between BPRI and AKI progression in HF patients.
methodsThis was a retrospective cohort study collected the data from MIMIC-IV version 3.0. We collected the minimum value of BPRI within 24 hours of ICU admission (T0). The AKI progression was defined as an increase of at least one AKI stage within 48 hours after T0 (T1). The new incidence of AKI at T1 was also considered as AKI progression. The patients were divided into four distinct groups based on the quartiles of the BPRI.
resultsA total of 3147 patients with HF were included, of whom 1883 (59.8%) were male and a median age of 73.80 [64.50, 82.33] years. 1571 (49.9%) experienced AKI progression. The quartiles 1 group exhibited the lowest 90-day survival rate, especially in patients who developed AKI progression (all log-rank p < 0.001). Compared to the patients in quartiles 1, those in higher quartiles had a significantly lower risk of AKI progression (in full-adjusted model: quartiles 2 OR 0.94, 95% CI 0.77–1.17, p = 0.594; quartiles 3 OR 0.64, 95% CI 0.52–0.79, p < 0.001; quartiles 4 OR 0.70, 95% CI 0.56–0.87, p = 0.001). There was an asymmetric U-shaped relationship between BPRI and AKI progression, with a cutoff value of 12.0 (P-overall < 0.001, P-non-linear < 0.001). Similar results in stratified analyses based on the AKI situation (without AKI, AKI stage 1, AKI stage 2) at T0 were observed (compared to quartiles 1 group, the OR of other quartiles group were less than 1).
conclusionsWhen below the cut-off, a lower BPRI within the first 24 hours of ICU admission is associated with increased risk of AKI progression in the following 48 hours among HF patients, regardless of initial AKI situation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.