ArticleNature communications2025
Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Principle-based crisis prioritization: insights from the amygdala-hippocampus-prefrontal cortex network-mediated threat response.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- SORDINO: silent, sensitive, specific and artifact-resistant fMRI in awake, behaving mice.Nature neuroscience · 2026Article
- The impact of different decibels of ambient noise on attention.Scientific reports · 2026Article
- Spatiotemporally dynamic noradrenergic regulation of cortical networks.bioRxiv : the preprint server for biology · 2026Article
- A Novel Combined Audiovisual-Semantic Digital Tool for Early-Stage Cognitive Decline Detection: Development and Validation Study.JMIR aging · 2026Article
- Chronic stress-induced LC-NE dysfunction: cellular and axonal mechanisms underlying impaired neuromodulation.Frontiers in neuroscience · 2026Review
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Arousal states dynamically shape brain function and behavioral performance, as posited by the Yerkes-Dodson law. Yet, functional network substrates underlying this inverted U-shaped pattern remain unknown. Here, by integrating functional magnetic resonance imaging (fMRI) with simultaneous electroencephalography (EEG) across humans and awake mice, we found arousal modulated inverted U-shaped global functional connectivity (FC) dynamics, peaking at middle arousal level. Such inverted U-shaped FC exhibited significant correlation with arousal modulated behavioral performance, recapitulating the Yerkes-Dodson framework at the functional network level. Further combining invasive multimodal neural recording and manipulations of locus coeruleus-norepinephrine (LC-NE) neurons with awake mouse EEG-fMRI, we revealed the causal contribution of LC-NE system to arousal modulated FC dynamics, in which the inverted U-shaped pattern was dependent on the baseline arousal level. To summarize, we uncovered the functional network basis of the Yerkes-Dodson law, which was causally driven by the NE-mediated arousal fluctuations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.