Evidence map›Paper›PMID 41392140›Full record

ArticleJournal of nanobiotechnology2025

Ultrasound-enhanced and cell-traction-induced piezoelectric scaffolds for repairing bone defects.

Xing Zhang, Meifei Lian, Juncen Zhou, Ruida Xu, Zhiguang Qiao, Jinwu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xing ZhangShanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.
Meifei LianDepartment of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Juncen ZhouDepartment of Biomedical Engineering, University of Stony Brook, 100 Nicolls Rd, Stony Brook, 11794, NY, USA.
Ruida XuDepartment of Orthopaedic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, South Campus, Shanghai, 201112, China. xrd_1984@sina.com.
Zhiguang QiaoShanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. dr_qiaozhiguang@163.com.
Jinwu WangShanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. wangjw-team@shsmu.edu.cn.

Funding

the National Key R&D Program of China 2022YFA1104600the Project of Shanghai Science and Technology Commission 25HC2830400
6 · The paper itself

Abstract

The global increase in traumatic accidents and aging population has brought bone tissue injury and disease to the forefront of global health concerns. Traditional treatment methods face significant challenges, emphasizing the urgent need for advanced bone tissue repair techniques. The bioelectric phenomenon in natural bones is essential for bone development and fracture healing. Therefore, developing innovative repair strategies that replicate or enhance this electric field is expected to promote bone tissue repair and integration. Developing new electroactive tissue engineering scaffolds based on electromechanical interactions between cells and the extracellular matrix is essential. This article introduces a piezoelectric scaffold, initially fabricated using melt electro-writing, and then coated with a surface piezoelectric coating using electrospraying (ES) technology. The scaffold exhibits suitable stiffness similar to the extracellular matrix, and the piezoelectric coating can provide necessary electrical stimulation under cell traction. Furthermore, ultrasound technology was utilized to effectively replicate the electrical microenvironment of natural bone repair. The synergy of cell traction-induced electrical stimulation and ultrasound-enhanced scaffold piezoelectricity can substantially enhance bone tissue regeneration and repair. This study introduces a novel method for developing electroactive tissue engineering scaffolds, providing a promising solution for non-load-bearing areas' bone defects via electrical stimulation.

Indexed as

Bone and BonesBone RegenerationTissue EngineeringTissue ScaffoldsAnimalsElectric StimulationHumansUltrasonic WavesCell tractionElectrical stimulation osteogenesisElectrosprayingMelt electro-writingPiezoelectric scaffoldsUltrasound

Identifiers

PMID41392140
PMCPMC12821937

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.