SynthesisAnnals of medicine2025
Critical shift phase in deep vein thrombosis development after major sellar region tumor surgeries: a systematic review.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSellar region tumors, such as craniopharyngiomas, pituitary adenomas, and chordomas, pose substantial surgical complexity. Although outcomes have improved, venous thromboembolism (VTE), particularly deep vein thrombosis (DVT), remains a significant postoperative risk. While prior studies report elevated VTE incidence in neurosurgery, the specific mechanisms and timing of peak vulnerability after sellar tumor surgery are not well established.
objectiveThis study aims to identify the critical shift phase of heightened DVT risk after major sellar region tumor resections and to elucidate the pathophysiologic role of perioperative neuroendocrine disturbances in inducing a hypercoagulable state.
methodsA systematic review was performed according to PRISMA guidelines, assessing studies from PubMed, Cochrane Library, and ScienceDirect (October 2024-February 2025). Eligible studies evaluated neuroendocrine changes and DVT outcomes after sellar tumor surgery. Screening involved two independent reviewers with adjudication by a third. The review was registered in PROSPERO (CRD42024616487).
resultsThree studies met inclusion criteria. Evidence consistently indicates that the first 10 postoperative days represent the peak DVT-risk interval, corresponding to the neuroendocrine transition from central diabetes insipidus (CDI) to syndrome of inappropriate antidiuretic hormone secretion (SIADH). This shift produces abrupt sodium fluctuations, endothelial irritation, and fluid imbalance, collectively fostering a transient but pronounced hypercoagulable state.
conclusionsSellar region tumor resection precipitates a critical shift phase in the first 10 days postoperatively, during which neuroendocrine-fluid imbalances drive hypercoagulability. Early, individualized thromboprophylaxis, tailored to serum sodium and fluid status from post operative state, may mitigate this risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.