ArticleEJHaem2025
Successful Birth After First-Trimester Ravulizumab Exposure in a Patient With Paroxysmal Nocturnal Hemoglobinuria: A Case Report.
Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder treated with complement C5 inhibitors. While eculizumab (Ecu) has documented safety in pregnancy, data on ravulizumab (Rav) are scarce. We report a 25-year-old woman with PNH who experienced inadvertent Rav exposure at 8 weeks of pregnancy before switching to Ecu. Despite requiring transfusions, she delivered a healthy infant at term without anomalies or thrombosis. This case represents one of the earliest reports of Rav use in pregnancy, suggesting potential safety. Further data are needed, and multidisciplinary management remains essential for pregnant patients with PNH. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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