Evidence map›Paper›PMID 41393274›Full record

ArticleEuropean heart journal. Imaging methods and practice2025

Coronary artery stenosis, plaque burden, and severity of myocardial ischemia.

Tanja Kero, Juhani Knuuti, Sarah Bär, Jeroen J Bax, Antti Saraste, Teemu Maaniitty

Abstract read
In one paragraph

Article in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tanja KeroNuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0009-0008-2002-8699
Juhani KnuutiTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
Sarah BärTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0003-0045-6596
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Antti SarasteTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0003-2488-0893
Teemu MaaniittyTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0001-5819-4635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The relationship between the extent and composition of coronary atherosclerosis and the severity of myocardial ischaemia remains incompletely understood. We assessed whether artificial intelligence-guided coronary computed tomography angiography-derived plaque burden and composition correlate with ischaemia severity. Methods and results: We included 837 symptomatic patients undergoing coronary computed tomography angiography and subsequent Conclusion: Artificial intelligence-guided coronary computed tomography angiography-derived measures of plaque burden and stenosis are associated with the severity of myocardial ischaemia, although overlapping distributions across ischaemia severity indicate that anatomical imaging alone may be insufficient for accurate phenotyping of flow-limiting CAD. These findings encourage for the integration of functional imaging with quantitative plaque analysis for a more comprehensive evaluation of coronary artery disease.

Indexed as

artificial intelligencecoronary computed tomography angiographycoronary plaqueischaemiapositron emission tomography

Identifiers

PMID41393274
PMCPMC12696412

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.