Evidence map›Paper›PMID 41393296›Full record

ArticleFrontiers in endocrinology2025

Parent-of-origin effects of phosphatidyl inositol-bisphosphate hydrolysis pathway genes on type 2 diabetes and the modification effect by obesity.

Yinxi Tan, Hexiang Peng, Siyue Wang, Poning Hu, Yi Zheng, Haodong Zhang, Huangda Guo, Yixin Li, Hanyu Zhang, Yiqun Wu and 6 more

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In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yinxi TanDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.
Hexiang PengDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Siyue WangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Poning HuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.
Yi ZhengDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.
Haodong ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.
Huangda GuoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Yixin LiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.
Hanyu ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Yiqun WuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Xueying QinDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Jing LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Tao WuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Dafang ChenDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Yonghua HuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Mengying WangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the parent-of-origin effects (POEs) of genes in the phosphatidyl inositol-bisphosphate (PIP2) hydrolysis pathway on type 2 diabetes (T2D) and preliminarily assess whether environmental factors may modify these effects. Methods: Based on data from an ongoing family-based cohort in Beijing, genetic information of 162 individuals from 53 case-parent triads was used to examine the POE of single nucleotide polymorphisms (SNPs) in the PIP2 pathway on T2D using maximum likelihood estimation based on a log-linear model. Stratified analyses were performed to assess the potential modification of POE by environmental factors, including smoking, drinking, and body mass index (BMI). Further enrichment analysis was conducted based on the POE results. Results: A total of 214 SNPs from the PIP2 hydrolysis pathway had nominally significant ( Conclusion: The current study provides a preliminary hint that SNPs in the PIP2 pathway genes may exhibit POE on T2D, contributing to its heritability. Notably, five SNPs in the

Indexed as

Diabetes Mellitus, Type 2ObesityPhosphatidylinositol 4,5-DiphosphatePolymorphism, Single NucleotideAdultBody Mass IndexCohort StudiesFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansHydrolysisMaleMiddle AgedParentsPhosphatidylinositol 4,5-Diphosphatecase-parents triadcohort studyinteraction analysisparent-of-origin effecttype 2 diabetes

Identifiers

PMID41393296
PMCPMC12695578

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.