ReviewFrontiers in endocrinology2025
Fertility in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a review.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Menarche in the third decade: congenital adrenal hyperplasia masquerading as Mayer-Rokitansky-Küster-Hauser syndrome.JCEM case reports · 2026Article
- Epidemiology, Etiopathogenesis, Diagnosis, and Treatment of Male Infertility-Current Trends and Future Directions: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Sex differences in classic congenital adrenal hyperplasia: a multicenter, real-world analysis.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is a rare autosomal recessive disorder affecting adrenal steroidogenesis, leading to cortisol deficiency, androgen oversecretion and adrenal glands' hyperplasia. While neonatal screening programs facilitate early diagnosis and treatment, CAH remains a complex condition with significant implications for fertility in both men and women. Women with CAH may experience menstrual irregularities, anovulation, prenatal virilization and psychological problems, while men face the problem of testicular adrenal rest tumors (TARTs), which can impair spermatogenesis, as well as experience sexual dysfunctions. Despite advances in the management of CAH, the issues of fertility and quality of sexual life still pose a challenge in this group of patients. This review aims to present the topic of fertility in CAH, taking into consideration the latest research and novel treatment options and underscores the importance of neonatal screening programs as well as personalized, team-based management to improve both reproductive outcomes and quality of life in CAH patients.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.