ArticleFrontiers in nutrition2025
Early enteral nutrition combined with supplemental parenteral nutrition vs. total parenteral nutrition after pancreaticoduodenectomy: a retrospective and propensity score-matched analysis of postoperative complications.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Postoperative nutritional support strategy after pancreaticoduodenectomy (PD) remains controversial. This retrospective study aims to evaluate early enteral nutrition (EEN) combined with supplemental parenteral nutrition (SPN) vs. parenteral nutrition (PN) as postoperative nutritional support, focusing on early clinical outcomes and postoperative complications in patients who underwent PD. Methods: Clinical data from consecutive patients who underwent PD between January 2022 and July 2024 were collected and analyzed in this retrospective study. The primary outcome was the incidence of postoperative complications. The secondary outcomes included specific postoperative complications, such as delayed gastric emptying (DGE), bile leak (BL), chyle leak (CL), acute pancreatitis (AP), postpancreatectomy hemorrhage (PPH), and infectious complications, compared between the two groups. A propensity score-matched (PSM) analysis was performed to balance baseline confounders between the groups. Results: According to perioperative nutritional protocols, 248 patients were included and divided into the EEN + SPN group ( Conclusion: In conclusion, this study demonstrates that for patients at nutritional risk following PD, EEN + SPN is a safe and feasible nutritional support strategy and is associated with a significant reduction in the incidence of severe complications.
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