SynthesisFrontiers in nutrition2025
Meta-analysis on the safety and efficacy of long-term garlic consumption as an adjunctive treatment for hypertension.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effectiveness of garlic clove (Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This systematic review and meta-analysis aimed to synthesize existing evidence, quantify the overall effect of garlic intervention on blood pressure, and explore potential variations in its effects under different population, formulation, and intervention duration conditions. This provides scientific evidence to support the clinical application of garlic in non-pharmacological interventions for hypertension. Methods: This systematic review and meta-analysis strictly adhered to the protocol registered with PROSPERO (CRD420251055848) and followed the guidelines outlined in the PRISMA statement. We conducted a comprehensive search of PubMed, Web of Science, Embase, and the Cochrane Library from their inception to May 10, 2025. Inclusion criteria were based on the PICOS framework: patients with a clear diagnosis of hypertension, treated with garlic or garlic products, compared with conventional medications or a placebo, with clearly defined outcome measures, and randomized controlled trials (RCTs). Meta-analysis was performed using Stata 14.0 software, assessing heterogeneity using the Results: A total of 1,877 articles were retrieved, with 10 RCTs ultimately included in the meta-analysis. The results indicated a significant reduction in systolic blood pressure (SBP) (effect size: -4.21, 95% CI: -5.74 to -2.69, Conclusion: This meta-analysis suggests that garlic intervention has a significant effect on reducing blood pressure in certain populations, including those who are obese, aged 50-60, or have higher DBP. However, the overall impact on hypertension may be limited. Potential gastrointestinal and other adverse effects should be considered in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.