ArticleFrontiers in pharmacology2025
Efficacy of sulfonamides targeting malic enzyme in an animal model of Chagas disease.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Nitrogen-Doped Graphene Quantum Dots Conjugated to Leucettinib-21 Rescue Differentiating Zebrafish Purkinje Cells by Inhibiting Dyrk1A Kinase.ACS applied nano materials · 2026Article
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: Even after a century since its discovery, Chagas disease remains a major public health concern. Benznidazole and nifurtimox are the only approved treatments, but their limited efficacy and adverse effects highlight the urgent need for new therapies. In the last decade, several phenotypic screenings performed by pharmaceuticals and academic groups revealed new promising compounds. In a previous study, we identified the Aim: The present study aims to evaluate the efficacy of new sulfonamides derived from TCMDC-143108 in an animal model for acute Chagas disease. Methods: The new sulfonamides were evaluated for TcME inhibition and activity against Results: Compounds AC-R008, AC-M109, and AC-M110 inhibited TcME and Conclusion: These findings demonstrate the potential of this sulfonamide scaffold while also underscoring metabolic instability and limited systemic exposure as major challenges. Future optimization efforts will focus on structural modifications and formulation strategies to enhance pharmacokinetics and therapeutic efficacy.
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