ArticleCureus2025
Increased Vitamin D Receptor Immunoreactivity in Endometrial Polyps: An Exploratory Single-Center Pilot Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to compare vitamin D receptor (VDR) immunoexpression in endometrial polyps and paired adjacent normal endometrium.
methodsSeventeen women (mean age, 48 ± 9 years) undergoing hysteroscopic polypectomy were included. Paired samples of polyp tissue and adjacent normal endometrium were analyzed by standardized immunohistochemistry using an anti-VDR monoclonal antibody. Two blinded pathologists independently assessed staining intensity (0-3) and fraction of positive cells (0-2), and calculated a composite van Slooten score (0-6). VDR positivity was defined as a composite score ≥ 3.
resultsVDR expression was higher in polyps than in normal endometrium. Mean intensity (1.5 ± 1.1 vs. 0.8 ± 0.8; p = 0.041), fraction of stained cells (1.1 ± 0.7 vs. 0.4 ± 0.7; p = 0.020), and composite score (2.6 ± 2.0 vs. 1.0 ± 1.5; p = 0.020) were significantly greater in polyps. VDR positivity was observed in 58.8% (10/17) of polyps and 23.5% (4/17) of normal endometrial samples (p = 0.037). Interobserver agreement was substantial to almost perfect (κ = 0.70-0.85). No association was observed between VDR score and age, BMI, or menopausal status.
conclusionsEndometrial polyps exhibit increased VDR expression compared with paired normal endometrium. These exploratory findings suggest compensatory VDR upregulation in benign proliferative lesions, warranting confirmation in larger molecular studies.
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