ArticlebioRxiv : the preprint server for biology2025
Restoration of MAIT cell function in healthcare-associated bacterial infections supports recovery of carbapenem efficacy against resistant bacteria.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antimicrobial resistance (AMR) presents a major clinical challenge to patients with healthcare-associated infections (HAIs), particularly among immunocompromised individuals and patients with comoribidites, who often exhibit an impaired mucosa-associated invariant T (MAIT) cell pool. MAIT cells are innate-like T cells enriched in mucosal tissues, possess potent antibacterial activity, and restoration of their function may offer a host-directed strategy against drug-resistant pathogens. We evaluated how stimulation with cognate antigen in combination with various cytokines, modulates MAIT cell cytotoxicity and enhances carbapenem activity. Under optimal conditions, MAIT cells exhibited increased expression of antimicrobial cytolytic proteins and efficiently killed cells pulsed with MAIT cell antigen. IL-15 or IL-2 plus IL-7 were particularly effective in promoting polyfunctional cytotoxic responses. Secretomes from cytokine-stimulated MAIT cells restored the activity of imipenem against engineered
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