Evidence map›Paper›PMID 41394696›Full record

ArticlebioRxiv : the preprint server for biology2025

Oligodendrocytes show enriched expression of amyloid precursor protein and GABA B receptor isoform 1a.

Samah Houmam, Dominika Siodlak, Meena Seshadri, Gideon B Hallum, Nathan P Pezant, David R Stanford, Casandra Salinas-Salinas, Yvonne M Thomason, Courtney G Montgomery, Heather C Rice

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samah HoumamAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.ORCID 0000-0002-8036-321X
Dominika SiodlakAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Meena SeshadriAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Gideon B HallumCenter for Biomedical Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Nathan P PezantCenter for Biomedical Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
David R StanfordCenter for Biomedical Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Casandra Salinas-SalinasAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Yvonne M ThomasonAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Courtney G MontgomeryCenter for Biomedical Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Heather C RiceAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.ORCID 0000-0002-5818-4338

Funding

Visualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Veronica Galvan, William Edmund Sonntag · 2019 to 2026
$17.8M
GEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6M
Research Supplements to Promote Diversity in Health-Related Research Mechanisms of APP ectodomain functionR35GM142726 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RICE, HEATHER C. · 2021 to 2025
$2.0M
The role of tetraspanin-regulated endolysosomal trafficking in Alzheimer's DiseaseR21AG085486 · NIA · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI RICE, HEATHER C. · 2024 to 2025
$449k
NIA NIH HHS R21 AG085486NIA NIH HHS T32 AG052363NIGMS NIH HHS P20 GM125528NIGMS NIH HHS R35 GM142726
6 · The paper itself

Abstract

Amyloid precursor protein (APP) is a type I transmembrane protein that undergoes proteolytic processing to generate amyloid-β, the main component of amyloid plaques found in brains with Alzheimer's disease. The proteolytic processing of APP also generates soluble APP alpha (sAPPα) which can modulate synaptic transmission and neurite outgrowth through the γ-aminobutyric acid type B receptor (GABA

Indexed as

Alzheimer’s diseaseAmyloid Precursor ProteinAPPGABABRGABA Receptorisoform-specific expressionOligodendrocytes

Identifiers

PMID41394696
PMCPMC12697541

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.