Evidence map›Paper›PMID 41394698›Full record

ArticlebioRxiv : the preprint server for biology2025

Recurrent expansion and rapid evolution of the Drosophilid RNAi pathway in testis.

Kimberly Elicker, Garima Setia, Meysoon Quraishi, Xin Yu Zhu Jiang, Lijuan Kan, Alex S Flynt, Jiayu Wen, Lamia Wahba, Eric C Lai

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kimberly ElickerLaboratory of Non-Canonical Modes of Inheritance, Rockefeller University, New York, NY 10065, USA.
Garima SetiaDevelopmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.
Meysoon QuraishiDevelopmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.
Xin Yu Zhu JiangDevelopmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.
Lijuan KanDevelopmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.
Alex S FlyntDepartment of Biomedical Engineering, University of Mississippi, University, MS 38677, USA.
Jiayu WenDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research The Australian National University, Canberra, Australia.
Lamia WahbaLaboratory of Non-Canonical Modes of Inheritance, Rockefeller University, New York, NY 10065, USA.
Eric C LaiDevelopmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.ORCID 0000-0002-8432-5851

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Michael Jason de la Cruz · 1985 to 2026
$347.4M
Selective regulatory and biogenesis mechanisms for microRNAsR01GM083300 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2007 to 2026
$9.8M
Essential roles for RNAi/hpRNAs to resolve intragenomic conflicts in the male germlineR01HD108914 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2022 to 2026
$2.9M
NCI NIH HHS P30 CA008748NICHD NIH HHS R01 HD108914NIGMS NIH HHS R01 GM083300
6 · The paper itself

Abstract

Multiple classes of selfish genetic elements, including transposable elements, meiotic drivers, and viruses, are suppressed by small interfering RNAs (siRNAs) that guide RNA interference (RNAi). These are interlocked within continually evolving genetic conflicts that are characterized by extremely rapid dynamics of change in both sequence and copy number. Indeed, it was shown that across

Identifiers

PMID41394698
PMCPMC12697358

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.