Evidence map›Paper›PMID 41394713›Full record

ArticlebioRxiv : the preprint server for biology2025

Thermally activated irreversible homogenization of G-quadruplexes in an ALS/FTD-associated gene.

Daniel Ross, Olivia Lewis, Olivia McLean, Sundeep Bhanot, Shane Donahue, Rachael Baker, Randi Dias, David Eagerton, Vaibhav Mohanty, Bidyut K Mohanty

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Daniel RossEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0009-0006-0923-1202
Olivia LewisEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0009-0008-1585-761X
Olivia McLeanEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0009-0002-4724-2333
Sundeep BhanotEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0009-0008-6748-0789
Shane DonahueEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0009-0001-8708-3106
Rachael BakerEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0009-0007-4145-5406
Randi DiasEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0009-0002-3697-2162
David EagertonEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0000-0003-0972-6169
Vaibhav MohantyDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0003-1475-4228
Bidyut K MohantyEdward Via College of Osteopathic Medicine-Carolinas Campus, Spartanburg, SC 29303.ORCID 0009-0001-1422-350X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A significant proportion of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases exhibit a substantial copy number expansion of the hexanucleotide GGGGCC/GGCCCC sequence in the

Identifiers

PMID41394713
PMCPMC12697674

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.