Evidence map›Paper›PMID 41394803›Full record

ArticleFrontiers in immunology2025

TSG-6 promotes healing of critical-sized bone defects in mice.

Oliver Küppers, Mubashir Ahmad, Sandra Dieterich, Jasmin Maria Bülow, Christoph Kölbl, Melanie Haffner-Luntzer, Karin Scharffetter-Kochanek, Anita Ignatius, Verena Fischer

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Oliver KüppersInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany.
Mubashir AhmadInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany.
Sandra DieterichInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany.
Jasmin Maria BülowInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany.
Christoph KölblInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany.
Melanie Haffner-LuntzerInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany.
Karin Scharffetter-KochanekDepartment of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany.
Anita IgnatiusInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany.
Verena FischerInstitute of Orthopaedic Research and Biomechanics, Ulm University Medical Center, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor necrosis factor-stimulated gene 6 (TSG-6) is recognized for its anti-inflammatory and pro-regenerative properties in various inflammatory conditions, including peritonitis, arthritis, traumatic brain injury, and corneal as well as skin wound healing. However, its regenerative role in bone metabolism and repair remains largely unexplored. This study aimed to address this gap. We observed an increased expression of

Indexed as

Bone RegenerationCell Adhesion MoleculesWound HealingAnimalsCell DifferentiationDisease Models, AnimalFemurMaleMesenchymal Stem CellsMiceMice, Inbred C57BLOsteogenesisCell Adhesion MoleculesTnfaip6 protein, mousebone healinginflammationM2 macrophage polarizationmesenchymal stem cellsosteogenic differentiationTSG-6

Identifiers

PMID41394803
PMCPMC12700086

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.