Pre-emptive role of oral melatonin in prevention of catheter-related bladder discomfort (CRBD) in patients undergoing transurethral resection of prostate (TURP) surgery: A randomised controlled study.

Background and Aims: Catheter-related bladder discomfort (CRBD) is a frequent and distressing complication following urological procedures such as transurethral resection of the prostate (TURP). Melatonin may reduce CRBD. This study aimed to evaluate the efficacy of pre-emptive oral melatonin in reducing CRBD in patients undergoing TURP. Methods: Seventy male patients aged 40-65 years scheduled for TURP under spinal anaesthesia were enroled in this randomised controlled trial. Group M received oral melatonin 5 mg the night before and the morning of surgery, while Group C received oral vitamin C 5 mg as a placebo. CRBD incidence and severity were assessed at 0, 2, 8, 12, and 24 h postoperatively. Sedation using the Ramsay sedation scale (RSS), patient satisfaction scale (PSS), surgeon satisfaction scale (SSS), and need for rescue analgesia was assessed. Statistical tests were two-tailed with a significance level set at Results: The incidence of CRBD was significantly reduced at 24 h in Group M as compared to Group C ( Conclusion: Preemptive oral melatonin effectively reduces the incidence and severity of postoperative CRBD in patients undergoing TURP.