ArticleJournal of pain research2025
No Evidence for a Causal Association Between Depression and Herpes Zoster or Post-Herpetic Neuralgia: A Mendelian Randomization Study.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: Observational studies have suggested a correlation between depression and herpes zoster (HZ), as well as post-herpetic neuralgia (PHN); however, the causal relationship remains unclear. This study aimed to assess the causal relationships between depression and HZ and PHN via a two-sample bidirectional Mendelian randomization (MR) approach. Methods: We collected data for major depressive disorder (MDD, 246,363 cases/561,190 controls), depressive status (442,840 individuals), HZ (7,132 cases/480,316 controls) and PHN (490 cases/435,371 controls) from genome-wide association studies (GWASs) in European populations, along with depression-related consultations (430 cases/2,152 controls) and zoster infections (2,209 cases/166,603 controls), for validation analysis in East Asian populations. We employed inverse variance weighted (IVW), MR-Egger, weighted median, weighted mode, and MR-PRESSO for our analysis. Results: Although suggestive, no statistically significant associations were found between genetic MDD and the risk of HZ (IVW, OR: 1.190, 95% CI: 0.984-1.439, Conclusion: A comprehensive MR study suggested that depression is not causally related to susceptibility to HZ or PHN, and vice versa. Future studies should focus on how environmental/clinical, not genetic factors that cause depression affect the risk of HZ and PHN.
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