Evidence map›Paper›PMID 41395244›Full record

ArticleTransboundary and emerging diseases2025

Celastrol Inhibits Porcine Epidemic Diarrhea Virus Replication by Promoting ROS-Mediated Apoptosis.

Junhai Zhu, Kaifang Yang, Pengfei Zhang, Hao Yuan, Nan Yan, Longxiang Zhang, Meiyu Jia, Yue Wang, Bin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junhai ZhuCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0000-0002-0346-0198
Kaifang YangCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0009-0001-2097-2080
Pengfei ZhangCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0009-0001-7626-8295
Hao YuanCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0009-0002-6952-4104
Nan YanCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0000-0002-5177-3893
Longxiang ZhangCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0009-0005-9612-7931
Meiyu JiaCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0009-0004-7489-0998
Yue WangCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0000-0003-1575-3569
Bin LiCollege of Veterinary Medicine, Southwest University, No 2, Tiansheng Street, Chong Qing, 400715, China, swu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) causes acute, highly contagious enteric disease in pigs, leading to severe economic losses, particularly due to high mortality in suckling piglets. Currently, no specific antiviral drugs are available. In this study, we evaluated the anti-PEDV potential of celastrol, a natural triterpenoid derived from

Indexed as

Antiviral AgentsApoptosisCoronavirus InfectionsPorcine epidemic diarrhea virusReactive Oxygen SpeciesTriterpenesVirus ReplicationAnimalsChlorocebus aethiopsPentacyclic TriterpenesSwineSwine DiseasesVero CellsAntiviral AgentscelastrolPentacyclic TriterpenesReactive Oxygen SpeciesTriterpenesantiviral drugapoptosiscelastrolnetwork pharmacologyporcine epidemic diarrhea virus

Identifiers

PMID41395244
PMCPMC12699546

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.