ArticleResearch (Washington, D.C.)2025
An Integrated Electrolysis-Enrichment Microchip for Ultra-Rapid and Sensitive mRNA Detection.
Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nanomaterial-nucleic acid probe synergy: accelerating rapid pathogen detection and antimicrobial susceptibility testing in bloodstream infections.Folia microbiologica · 2026Review
- Vertical-flow tearable paper-tape rolls for scalable multiplexed point-of-care nucleic acid testing.Microsystems & nanoengineering · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Messenger RNA (mRNA) detection plays a vital role in gene expression analysis, disease diagnosis, and precision medicine. However, current methods are limited by complex chemical-based extraction procedures and the rapid degradation of mRNA. To overcome these challenges, we developed an electrolysis-enrichment microfluidic chip (EEMC) that employs electricity-driven physical methods for ultra-rapid, efficient mRNA extraction directly from whole blood, eliminating the need for chemical reagents that can inhibit downstream analysis. By integrating electrolytic lysis with ion concentration polarization (ICP) enrichment, the EEMC completes the entire process within 10 min-6 times faster than conventional techniques, greatly avoiding the potential degradation. It achieves a high recovery efficiency of 90% to 95%, which surpasses the 85% to 90% efficiency of commercial RNA extraction kits. Combined with downstream loop-mediated isothermal amplification (LAMP), the EEMC provides a powerful solution for rapid mRNA processing and detection. Its efficacy was validated in radiation exposure models through the detection of key mRNA biomarkers (BAX, CDKN1A, and GADD45A). This environmentally friendly and high-performance platform advances point-of-care precision diagnostics.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.