ReviewAmerican journal of cancer research2025
CENPs in hepatocellular carcinoma: a comprehensive review of expression patterns, clinical correlations, and functional mechanisms.
Review in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Centromere protein I promotes hepatocellular carcinoma progression by activating PI3K/AKT/mTOR-CDK2 cascade.Cancer biology & therapy · 2026Article
- Integrative machine learning and multi-omics identify a centromere gene signature and validate B3GALT4 as a tumor suppressor in osteosarcoma.Journal of bone oncology · 2026Article
- The Prevalence and Clinical Significance of the Centromere Protein-F-Like Immunofluorescence Staining Pattern in a Large ANA-positive Cohort.Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is a major global health challenge, with poor prognosis for advanced patients. Centromere proteins (CENPs) play a critical role in maintaining genomic stability. To investigate the characteristics of CENPs in HCC and elucidate the mechanisms by which CENPs regulate HCC progression through interactive molecular networks, this review aims to provide new insights into HCC mechanisms and targeted therapies. Therefore, we retrieved peer-reviewed original research articles or reviews from the PubMed database, focusing on the current research status of CENPs in HCC, and detailed the expression levels of CENPs in HCC tissues, patient survival, clinicopathological features, immune infiltration, and intermolecular mechanisms. The study found that aberrant expression of CENPs has been confirmed to be significantly associated with HCC patient survival, clinicopathological characteristics, and tumor microenvironment immune infiltration. CENPs regulate HCC cell proliferation, invasion, migration, cell death, angiogenesis, and glycolysis through complex interactive molecular networks. This review provides valuable insights for basic research, the development of HCC biomarkers, and the research and development of targeted drugs.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.