Evidence map›Paper›PMID 41395320›Full record

ArticleIJTLD open2025

Clinical standards for antimicrobial stewardship in TB care.

T T Brehm, O W Akkerman, G Sotgiu, S Tiberi, K-C Chang, K Dheda, R Duarte, D Vambe, Z F Udwadia, D Chesov and 50 more

Abstract read
In one paragraph

Article in IJTLD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

60 authors.

T T BrehmDepartment of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
O W AkkermanDepartment of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
G SotgiuClinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
S TiberiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
K-C ChangTuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China.
K DhedaCentre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute and South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa.
R DuarteEPIUnit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
D VambeThe Global Tuberculosis Program, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Z F UdwadiaP.D. Hinduja National Hospital and Medical research Centre, Mumbai, India.
D ChesovDepartment of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
M MendelsonDivision of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa.
A M Iswari SaktiawatiDepartment of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
J van IngenDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
F O EyubogluFOE Respiratory Clinic, Ankara, Turkey.
T TängdénDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
L N Quang VoFriends for International TB Relief, Ha Noi, Vietnam.
N RiccardiStopTB Italia ODV, Milan, Italy.
C Moschos'Sotiria' Hospital for Chest Diseases, Anti-Tuberculosis Department and Drug Resistant TB Unit, Athens, Greece.
J S FriedlandInstitute of Infection and Immunity, City St. George's, University of London, London, UK.
T LillebaekInternational Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark.
S J ChandyDepartment of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, India.
J A CamineroPneumology Department, Universitary Hospital of Gran Canaria 'Dr. Negrín', Las Palmas de Gran Canaria, Spain.
G ThwaitesOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
S GandraDivision of Infectious Disease, Washington University School of Medicine, St. Louis, MO, USA.
K ThurskyDirector RMH Guidance Group, Melbourne, VIC, Australia.
I A GeorgeAssociate Hospital Epidemiologist, Barnes-Jewish Hospital, St. Louis, MO, USA.
O KonstantynovskaDepartment of Infectious Diseases and Clinical Immunology, V. N. Karazin Kharkiv National University, Kharkiv, Ukraine.
R FatimaTechnical Advisor Consultant TB Strategic Planning and Global Fund Applications UNOPS.
J-J YimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
N KwakDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
I D OlaruClinical Research Department, London School of Hygiene and Tropical Medicine, London, UK.
S H GillespieSchool of Medicine, Division of Infection and Global Health, University of St Andrews, St Andrews, UK.
Y KherabiInfectious and Tropical Diseases Department, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
S H PerlTuberculosis Departement, Ministry of Health, Jerusalem, Israel.
E GrønningenCentre for International Health, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
C RodriguesDepartment Lab Medicine, Hinduja Hospital, Mumbai, India.
S BjerrumDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark.
F BangeInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
V CoxJohnson & Johnson, Titusville, NJ, USA.
D M CirilloIRCCS San Raffaele Scientific Institute, Milan, Italy.
F SaluzzoIRCCS San Raffaele Scientific Institute, Milan, Italy.
G L HaraUnidad de Infectología, Hospital Carlos G Durand, Buenos Aires, Argentina.
D WagnerDivision of Infectious Diseases, Department of Internal Medicine II, Freiburg University Medical Centre, Freiburg, Germany.
N IsmailSouth African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
D J SloanSchool of Medicine, Division of Infection and Global Health, University of St Andrews, St Andrews, UK.
I Eshun-WilsonovaJohnson & Johnson, Cape Town, South Africa.
M ZengDepartment of Infectious Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
C CanteroService de Pneumologie, Département de Médecine, Hôpitaux Universitaires de Genève, Genève, Switzerland.
T VasankariDepartment of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
A MandalakasDepartment of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
A KayThe Global Tuberculosis Program, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
T NessThe Global Tuberculosis Program, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
M M TorricoClínica de Tuberculosis, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
G GüntherDepartment of Pulmonology, Allergology and Clinical Immunology, Inselspital Bern, Bern University Hospital, Bern, Switzerland.
L KuksaTuberculosis and Lung Disease Clinic, Riga East University Hospital, Riga, Latvia.
L GuglielmettiDepartment of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy.
A L García-BasteiroISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
G B MarksWoolcock Institute of Medical Research, Ba Dinh District, Vietnam.
C PulciniUniversité de Lorraine, Inserm, INSPIIRE, Nancy, France.
C LangeDepartment of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Funding

Wastewater surveillance to enhance the public health response to HIV and TB in EswatiniDP1HD115427 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Alexander William Kay · 2024 to 2026
$1.7M
NICHD NIH HHS DP1 HD115427
6 · The paper itself

Abstract

backgroundWhile antimicrobial stewardship (AMS) is essential for combating antimicrobial resistance (AMR), TB-specific AMS strategies remain poorly defined.

methodsAn international panel of 62 experts participated in a Delphi process. Using a 5-point Likert scale (5 = strong agreement; 1 = strong disagreement), participants evaluated 10 draft clinical standards developed by a core coordination team. A standard was adopted if ≥90% of respondents rated it three or higher, according to a predefined consensus threshold.

resultsAll 10 standards reached the consensus threshold and were adopted: Standard 1, integration of TB into national AMR action plans; Standard 2, implementation of TB surveillance systems; Standard 3, education of health care providers, individuals affected by TB, and the public; Standard 4, integration of TB into AMS activities; Standard 5, establishment of expert consultation services; Standard 6, targeted testing and preventive treatment for individuals at risk for TB; Standard 7, access to timely and comprehensive drug susceptibility testing; Standard 8, prioritisation of efficacy, safety, and resistance prevention in TB treatment regimens; Standard 9, clinical and microbiological monitoring of treatment response; and Standard 10, assessment of adherence, drug exposure, and resistance in treatment failure.

conclusionThese clinical standards aim to support clinicians, programme managers, and public health authorities in implementing effective, TB-specific AMS strategies.

Indexed as

antimicrobial resistancedrug resistancerifampicin resistancetuberculosis

Identifiers

PMID41395320
PMCPMC12699960

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.