ReviewFrontiers in dental medicine2025
CTLA-4 and targeted immunotherapy-a key link in the systemic influence of periodontitis: a mini review.
Review in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Periodontitis-Induced Immune Reprogramming: Implications for Cancer Immunotherapy Response.Biomedicines · 2026Review
- Regulation of immune checkpoints by electronic cigarette.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytotoxic T Lymphocyte Associated Protein 4 is a T cell-associated receptor that serves as an immune checkpoint molecule, downregulating immunosurveillance and propagating immune homeostasis. Periodontitis influences the serum levels of CTLA-4, which in turn alters the T cell activation pathways, PD-1 pathways, and CD80 activation, which has a key role in antigen presentation and implicates the B cell-mediated antibody response in periodontitis. In contrast, this elevation in CTLA-4 affects various other systemic immuno-inflammatory disorders, predominantly cancer and the efficacy of its immunotherapy. In the current article, an extensive literature review is conducted to elicit the link between the elevation of CTLA-4 in periodontitis and its possible influence on systemic immune-inflammatory disorders and their related targeted immune therapies. After investigation, CTLA-4 and its molecular therapy were found to have a crucial role in altering cancer pathogenesis, immunotherapy, and the pathogenesis of autoimmune disorders. The current article elaborates on the immuno-inflammatory pathways, molecular links, and plausible mechanisms linking periodontitis-associated CTLA-4 elevation and CTLA-4-based molecular therapy, specifically focusing on cancer immunotherapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.