ArticleFrontiers in microbiology2025
Human PMNs exhibit greater engulfment, NETosis, and enhanced migration when incubated with nontypeable
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
4 authors.
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Abstract
Biofilm-resident bacteria exhibit diverse mechanisms to evade eradication, including the highly protective self-produced matrix in which they are embedded. Thus, releasing bacteria from biofilm residence affords antibiotics and immune effectors greater access. We developed a monoclonal antibody directed against an essential biofilm matrix protein that induces rapid collapse of the biofilm matrix with release of bacteria that are in a transient but highly vulnerable phenotype. Bacteria that are newly released ("NRel") due to this monoclonal are significantly more sensitive to antibiotic-, antimicrobial peptide- or human PMN-mediated killing
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.