SynthesisCurrent pain and headache reports2025
CSI and Musculoskeletal Pain: Clinical Validity and Neurophysiological Implications.
Synthesis in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Central Sensitization as a Marker of Cognitive and Emotional Vulnerability in Chronic Low Back Pain.Brain sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimChronic pain affects about 20% of adults worldwide, severely impacting quality of life and functioning. Many chronic pain syndromes share symptoms such as fatigue, poor sleep, anxiety, and depression, suggesting a common mechanism. Central sensitization, an abnormal amplification of pain by the nervous system, is considered a key underlying factor. Assessment tools like the Central Sensitization Inventory (CSI) and laser-evoked potentials (LEPs) may improve diagnosis and guide targeted treatment strategies. This review evaluates the validity of the CSI for assessing central sensitization in chronic musculoskeletal pain. It also explores integrating objective measures like LEPs to enhance diagnosis and treatment strategies.
methodsA systematic review was conducted following PRISMA guidelines. Searches in PubMed, Web of Science, Cochrane Library, Embase, and Scopus included studies published before September 2025. After removing duplicates and non-English articles, titles and abstracts were screened, and full texts assessed for eligibility. Study quality was evaluated using the JBI checklists.
resultsFrom 557 retrieved studies, 8 met the inclusion criteria. All used the CSI, showing it as a valid and practical tool correlating with pain, disability, and impaired quality of life. However, limitations due to its subjective nature were noted.
conclusionsWhile CSI is valuable for initial screening, combining it with LEPs can provide a more precise and comprehensive assessment, improving diagnosis, management, and treatment personalization.
Indexed as
Identifiers
41396224What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.